Company Overview:

Prime Medicine is a leading biotechnology company dedicated to creating and delivering the next generation of gene editing therapies to patients. The Company is leveraging its proprietary Prime Editing platform, a versatile, precise and efficient gene editing technology, to develop a new class of differentiated, one-time, potentially curative genetic therapies. Designed to make only the right edit at the right position within a gene while minimizing unwanted DNA modifications, Prime Editors have the potential to repair almost all types of genetic mutations and work in many different tissues, organs and cell types.

Prime Medicine is currently progressing a diversified portfolio of investigational therapeutic programs organized around our core areas of focus: hematology, immunology & oncology, liver and lung. Across each core area, Prime Medicine is focused initially on a set of high value programs, each targeting a disease with well-understood biology and a clearly defined clinical development and regulatory path, and each expected to provide the foundation for expansion into additional opportunities. For more information, please visit www.primemedicine.com.

Co-op Assignment Overview

Prime Medicine is seeking a Co-op student for the Spring 2026 semester with a strong background in chemistry or biochemistry to join our guide RNA chemistry team. The selected candidate will contribute to the synthesis, purification, and analysis of oligonucleotides. This position provides hands-on experience with nucleic acid techniques, oligonucleotide characterization, data documentation, and opportunities to present findings in team meetings. We welcome curious, collaborative problem solvers who are passionate about advancing gene-editing technologies to improve human health.

Key Responsibilities:

Perform solid-phase synthesis of oligonucleotides using automated DNA/RNA synthesizers such as the Mermade12.
Support purification and analysis of oligonucleotides with HPLC, UPLC, and LCMS.
Prepare buffers and manage inventories of chemicals, reagents, and consumables.
Assist with maintenance and troubleshooting of laboratory equipment, including synthesizers, speedvacs, lyophilizers, and HPLC systems.
Maintain accurate electronic laboratory notebooks (ELNs), analyze and present data, and uphold safe laboratory practices.
Coordinate with scientists to maintain an oligonucleotide inventory for the final released guide RNA

Qualifications:

Current B.S. candidate in Chemistry, Biochemistry, or a related field; basic knowledge of organic chemistry preferred.
Prior experience working in a chemistry or biochemistry laboratory.
Strong organizational skills with the ability to prioritize and meet deadlines in a fast-paced environment.
Proficiency with common computer applications (Excel, Word, PowerPoint).
Excellent troubleshooting and communication skills.
Ability to work independently as well as collaboratively in a team.

Preferred Qualifications:

Exposure to nucleic acid chemistry through coursework or laboratory experience.
Familiarity with analytical techniques such as HPLC, UPLC, or LCMS gained through academic labs or internships.

What We Offer:

A cutting-edge team open to mentorship and networking.
Full reimbursement for monthly commuting costs including MBTA, Commuter Rail, or Bluebikes, etc.
Participation in regular seminars with industry experts.
Full participation in employee activities including learning and development offerings, social activities, etc.

NOTE: We are currently not considering co-op candidates outside of the local Boston/Cambridge area.

Prime Medicine is proud to be an equal opportunity employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, national origin, age, sexual orientation, gender identity, disability, veteran status, or any other classification protected by law.

Co-op: Small-Scale Guide RNA Chemistry

Guide RNA Chemistry

Prime Medicine