Delivery Science Co-op

Orna Therapeutics, Inc. is a Watertown-based biotechnology startup on a mission to create therapies for diseases inaccessible to existing approaches. Built on novel circular RNA technology developed at MIT, Orna is leading the next wave of RNA therapeutics with our best-in-class expression and delivery platform.

We are seeking a highly motivated Co-Op to join our Delivery Science team Watertown, MA. The successful candidate will work to develop, optimize, and evaluate targeted lipid nanoparticle (LNP) formulations for the in vivo delivery of therapeutic cargos.  In this cross-functional, fast-paced role, she/he will gain technical hands-on experience in bioconjugation and formulation development.  A suitable candidate will show passion and enthusiasm for understanding targeted drug delivery for developing next-generation therapies for patients suffering from genetic diseases.

Responsibilities

• Assist in developing experimental plans for bioconjugation of antibodies, proteins and peptides in lipid nanoparticles.
• Conduct optimization experiments with guidance.
• Maintain up-to-date and detailed records of laboratory procedures, results, and conclusions in electronic lab notebook system
• Design and support LNP and bioconjugation analytical characterization
• Perform routine LNP and oRNA analysis
• Run standard and design novel HPLC and MS methods with guidance.
• Execute and design experiments in collaboration with the overall Production team to meet timelines and deliverables
• Assist in data management and trending
• Provide hands-on assistance with good lab practices (i.e. inventory creation and maintenance; lab organization and safety compliance; equipment tracking, maintenance and service issues; etc)
• Deliver verbal updates or oral presentations during internal scheduling meetings

Qualifications

• B.S. or M.S. candidate in biochemistry, chemistry, chemical engineering, or a related field
• Ability to communicate and handle multiple projects in a fast-paced environment.
• Independently motivated, detail-oriented, and excellent problem-solving abilities
• Hands on lab experience is preferred.

Why work at Orna?  

In addition to working alongside bright and hardworking individuals, you’ll have the opportunity to experience an array of benefits throughout your time with us, including:  

• Daily lunch stipend
• Invitations to company outings and social events  
• Opportunities to meet with our Executive and Management teams  
• Participation in department specific and organization wide meetings and trainings  
• Various personal and professional development opportunities  
• Transportation or parking expenses  
• Company swag  
• Coverage under MA Sick Time and MA Paid Family and Medical Leave  
• Paid holidays, except company shutdowns, and two days of vacation, eligible after a 90-day probationary period  

 Equal Employment Opportunity Statement

Individuals seeking employment at Orna Therapeutics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation. 

#LI-DNI